El potencial terapéutico de las células madre. Eticidad del uso de las células madre embrionarias
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Ver Thomson, J. A., Itskovitz Eldor, J., Shapiro, S. S., Walknitz, M. A., Swiergiel, J. J.,
Marshall, V. S., Jones, J. M. (1998). Embryonic stem cell lines derived from human blastocysts,
Science 282: 1145-1147.
Shamblott, M. J., Axelman, J. Wang, S., Bugg, E. M., Littlefield, J. W., Donovan, P. J.,
Blumenthal, P. D., Huggins, G. R., Geathart, J. D. (1998). Derivation of pluripotent stem cells
from cultured human primordial germ cells. Proceedings National Academy of Science U.S.A.
: 13726-13731.
Ver Bjornson, C. R. R., Rietze, R. L., Reynolds, B. A., Magli, M. C., Vescovi, A. L. (1999).
‘Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo’.
Science 283: 534-537.
Ver Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N.,
Boggs, S. S., Greenberger, J. S., Goff, J. P. (1999). Bone marrow as a potential source of hepatic
oval cells. ‘Science’ 284: 1168-1170.
Krause, D. S., Theise, N. D., Collector, M. I., Herogariu, O., Gardner, R., Neutzel, S., Sharkis,
S. J. (2001). Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.
‘Cell’ 105: 369-377.
Ver Pittenger, M. F., MacKay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D.,
Moorman, M. A., Simonetti, D. W., Craig, S., Marshak, D. R. (1999). Multilineage potential of
adult human mesenchymal stem cells. ‘Science’ 284: 143-147.
Toma, J. G., Akhavan, M., Fernandes, K. J., Barnabe-Heider, F., Sadikot, A., Kaplan, D. R.,
Miller, F. D. (2001). ‘Isolation of multipotent adult stem cells from the dermis of mammalian’
skin. Nature Cell Biology 3: 778-784.
Bongso, A., Fong, C. Y., Ng, S. C., Ratnam, S. (1994). ‘Isolation and culture of inner cell mass
cells from human blastocysts’. Human Reproduction 9: 2110-2117.
Itskovitz- Eldor, J., Schukdner, M., Karsenti, D., Eden, A., Yanuka, O., Amit, M., Soreq, H.,
Benvenisty, N. (2000). ‘Differentiation of human embryonic stem cells into embryoid bodies
comprising the three embryonic germ layers’. Molecular Medicine 6: 88-95.
Kaufman, D. S., Hanson, E. T., Lewis, R. L., Auerbach, R., Thomson, J. A. (2001).
‘Hematopoietic colony forming cells derived from human embryonic stem cells’. Proceedings
National Academy of Science USA 98: 10716-10721.
Shamblott, M. J., Axelman, J., Littlefield, J. W., Blumenthal, P. D., Huggins, G. R., Cui, Y.,
Cheng, L., Geathart , J. D. (2001). ‘Human embryonic germ cell derivatives express a broad
range of developmentally distinct markers and proliferate extensively in vitro’. Proceedings
National Academy of Science U.S.A. 98: 113-118.
Ver Thomson, J. A., Itskovitz Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J.,
Marshall, V. S., Jones, J. M. (1998). ‘Embryonic stem cell lines derived from human
blastocysts’. Science 282: 1145-1147.
Ver Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J.,
McKay, R., Nadal-Ginard, B., Bodine, D. M., Lerl, A., Anversa, P. (2001). ‘Bone marrow cells
regenerate infarcted myocardium’. Nature 410: 701-705.
Ver Kocher , A. A., Schuster, M. D., Szabolcs, M. J., Takuma, S., Burkhoff, D., Wang, J.,
Homma, S., Edwards, N. M., Itescu, S. (2001). ‘Neurovascularization of ischemic myocardium
by human bone-marrow-derived angioblasts prevents cardiomyocites apoptosis, reduces
remodeling and improves cardiac function’. National Medicine 7: 430-436.
Beltrami, A. P., Urbanok, K., Kasjtura, J., Yan, S. M., Finato, N., Bussani, R., Nadal-Ginard,
B., Silvestri, F., Leri, A., Beltrami, C. A., Anversa, P. (2001). ‘Evidence that human cardiac
myocites divide after myocardial infarction’. New England Journal of Medicine 344: 1750-1757.
Ver Itskovitz-Eldor, J., Schuldner, M., Karsenti, D., Eden, A., Yanuka, O., Amit, M., Soreq,
H., and Benvenisty, N. (2000). ‘Differentiation of human embryonic stem cells into embryoid
bodies comprising the three embryonic germ layers’. Molecular Medicine 6: 88-95; y Kehat, I.,
Kenyagin-Karsenti, D., Druckmann, M., Segev, H., Amit, M., Gepstein, A., Livine, E., Binah,
O., Itskovitz-Eldor, J., Gepstein, L (2001). ‘Human embryonic stem cells can diffrentiate into
myocites portraying cardiiomyocitic structural and functional properties’. Journal Clinical
Investigation 108: 407-414.
Ver McKay, R. (1997). ‘Stem cells in the central nervous system’. Science 276: 66-71; y
Shihabuddin, L. S., Palmer, T. D., Gage, F. H. (1999). The Search for neural progenitor cells:
prospects for the therapy of neurodegenerative disease. Molecular Medicine Today 5: 474-480.
Ver Conti, L., Sipione, S., Magrassi, L., Bonfanti, L., Rigamonti, D., Pettirossi, V.,
Peschanski, M., Haddad, B., Pelicci, P, Milanesi, G., Pelicci, G., Cattaneo, E. (2001).
‘Hematopoietic colony-forming cells derived form human embryonic stem cells’. Proceedings
National Academy of Science U.S.A. 98: 10716-10721.
Ver Soria, B., Roche, E., Berna, G., Leon-Quinto, T., Reig, J. A., Martin, F. (2000). ‘Insulinsecreting
cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced
diabetic mice’. Diabetes 49: 157-162.
Ver Assady, S., Maor, G., Amit, M., Itskovitz-Eldor, J., Skorecki, K. L., Tzukerman, M.
(2001). ‘Insulin production by human embryonic stem cells’. Diabetes 50: 1691-1697.
Ver Traynor, A. E., Schroeder, J., Rosa, R. M., Cheng, D., Stefka, J., Mujais, S., Baker, S.,
Burt, R. K. (2000). ‘Treatment of severe systemic lupus erythematosus with high-dose
chemotherapy and haematopoietic stem-cell transplantation: a phase I study’. Lancet 356: 701-
Ver Kim, S. H., Kim, S., Evans, C. H., Ghivizzani, S. C., Oligino, T., Robbins, P. D. (2001).
‘Effective treatment of established murine collagen-induced arthitis by systemic administration
of dendritic cells genetically modified to express IL-4’. Journal of Inmunology 166: 3499-3505.
Ver Fairchild, P. J., Brook, F. A., Gardner, R. L., Graca, L., Strong, V., Tone, Y., Tone, M.,
Nolan, K. F., Waldmann, H. (2000). ‘Directed differentiation of dendritic cells from mouse
embryonic stem cells’. Current Biology 10: 1515-1518.
Ver Shiels, P. G., Kind, A. J., Campbell. K. H. S., Waddington, D., Wilmut, I., Colman, A.,
Schnieke, A. E. (1999). ‘Analysis of telomere lenghts in cloned sheep’. Nature 399: 316-317.
Bartolomei, M.S., Tilghman, S. M. (1997). Genomic imprinting in mammals.
Annual Review Genetics 31: 493-525.
Ver Chen, W. Y., Townes, T. M. (2000). ‘Molecular mechanism for silencing virally
transduced genes involves histone deacetylation and chromatin condensation’. Proceedings
National Academy of Science U. S. A. 97: 377-382.
Ver Armstrong, L., Lako, M., Lincoln, J. Calms, P. M., Hole, N. (2000). ‘MTert expression
correlates with telomerase activity during the differentiation of murine embryonic stem cells’.
Mechanisms Development 97: 109-116; y Yoder, M. C., Hiatt, K. (1999). ‘Murine yolk sac and
bone marrow hematopoietic cells with high proliferative potential display different capacities for
producing colony-forming cells ex vivo’. Journal of Hematology Stem Cell Research 8: 421-430.
Ver Amit, M., Carpenter, M. K., Inokuma, M. S., Chiu, C. P., Harris, C. P., Waknitz, M. A.,
Itskovitz-Eldor, J., Thomson, J. A. (2000). ‘Clonally derived human embryonic stem cells lines
maintain pluripotency and proliferative potential for prolonged periods of culture’.
Developmental Biology 227: 271-278.
Ver Luther-Wyrsch, A., Costello, E., Thali, M., Buetti, E., Nissen, C., Surbek, D., Holzgreve,
W., Gratwohi, A., Tichell, A., Wodnar Fillpowicz, A. (2001). ‘Stable transduction with lentiviral
vectors and amplification of immature hematopoietic progenitors from cord blood of
preterm human fetuses’. Human Gene Therapy 12: 377-389; y Shields, L. E., Klem, H. P.
Andrews, R. G. (2000). ‘Highly efficient gene transfer into preterm CD34+ hematopoietic
progenitor cells’. American Journal Obstetrics Ginecology 183: 732-737.
Asíhan especulado Geathart, J. (1998). ‘New potential for human embryonic stem cells’.
Science 282: 1061-1062; y Rathjen, P. D., Lake, J., Whyatt, L. M.Bettess, M. D., Rathjen, J.
(1998). ‘Properties and uses of embryonic stem cells: prospects for application to human biology
and gene therapy’. Reproductive Fertility Development 10: 31-47.
Para una discusión científica sobre el comienzo de la vida humana ver Rodríguez, E. (1999).
‘El estatuto del preembrión, una perspectiva biológica’. Ars Medica 1: 99-108.
Pearson, H. (2002). ‘Developmental biology: Your destiny, from day one’. Nature 418: 14-
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